Drug crystal form bincike da kuma daidaito kimantawa

Sa ido kan layi yana ba da sakamako mai sauri don gwajin kristal da aka yi niyya, ci gaba da bayanai yana haifar da hanyoyin amsawa da wuraren ƙarshe, samar da haɓakawa, kwatance.

Siffofin kristal daban-daban na miyagun ƙwayoyi na iya nuna bambance-bambance masu mahimmanci a cikin bayyanar, solubility, ma'anar narkewa, ƙimar rushewa, bioavailability, da dai sauransu, ta haka yana tasiri ga kwanciyar hankali, bioavailability, da inganci na miyagun ƙwayoyi.Sabili da haka, ya zama dole don tabbatar da kasancewar nau'in crystal ɗin da aka yi niyya yayin haɗar magunguna da hanyoyin ƙirƙira.

A cikin aiwatar da haɓaka sabon magani, ya zama dole don saka idanu a cikin ainihin lokacin abun da ke tattare da ƙwayar kristal na miyagun ƙwayoyi a cikin maganin amsawa.Anyi wannan don inganta tsarin da kuma tabbatar da cewa an haɗa lokacin da aka yi niyya na miyagun ƙwayoyi.Za a iya amfani da spectroscopy na Raman don saka idanu a cikin wurin, yana ba da cikakken bincike na lokaci-lokaci na abun da ke ciki na lokaci na crystalline a cikin halayen halayen ƙwayoyi, musamman dacewa don cikakken nazarin tsarin polymorphic da amorphous API-dauke da tsarin.

Kan layi Raman spectroscopy yana daidaita gwajin lokaci na crystal don yanayi daban-daban, kamar yadda gwajin wani kamfani na magunguna ya kwatanta.Sakamakon ya tabbatar da daidaitawa tare da kayan aikin magunguna masu aiki, yana nuna nasarar bincike.Iyakokin da suka gabata ta amfani da XRD da sauran kayan aikin lab sun haifar da ƙuntatawar bayanai da haɓaka haɓaka haɓaka.Wani shari'ar kuma ya nuna nasarar bambance-bambancen sauye-sauyen lokaci na kristal a cikin matakai daban-daban guda shida, yana ba da haske nan take cikin sakamakon samfur.